by HAF

May 27, 2021

from HumansAreFree Website

 

 

 

 

 



An article written by Dr. Tamara Bhadari, a senior science writer from the Washington University School of Medicine (WUSM) in St. Louis, recently published a below article explaining that,

even a mild COVID-19 infection induces lasting antibody protection that can last a lifetime...

She cites a study recently published from researchers at Washington University School of Medicine in St. Louis showing that the protection gained from mild COVID-19 illness,

"leave those infected with lasting antibody protection and that repeated bouts of illness are likely to be uncommon."

"Last fall there were reports that antibodies wane quickly after infection with the virus that causes COVID-19, and mainstream media interpreted that to mean that immunity was not long-lived.

 

But that's a misrepresentation of the data.
 

It's normal for antibody levels to go down after acute infection, but they don't go down to zero; they plateau.

 

Here, we found antibody-producing cells in people 11 months after first symptoms. These cells will live and produce antibodies for the rest of people's lives.

 

That's strong evidence for long-lasting immunity."

Ali Ellebedy

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

The study found that of 19 people who had a mild COVID infection, 15 of them contained-antibody-producing cells,

"specifically targeting the virus that causes COVID-19."

The cells are present in the bone marrow and constantly secreting antibodies. According to the researchers:

"They have been doing that ever since the infection resolved, and they will continue doing that indefinitely."

People who were infected and never had symptoms also may be left with long-lasting immunity, the researchers speculated.

 

What needs to happen next are multiple studies looking into the response and antibody level of those who were completely asymptomatic and those with severe infection, which suggests a higher viral load.

 

The studies that have emerged regarding the protection one receives from a COVID infection all point to the idea that immunity may last a lifetime.

 

This would be on par with what we've seen with other coronaviruses. Natural infection provides robust protection in the form of T cells, B cells and antibodies.

 

For example, did you know people who have had SARS still have robust immunity 17 years later?

 

A study published in Nature explains,

"In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein.

 

Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARCS-C0V infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-C0V 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS C0V-2…

 

These findings demonstrate that virus-specific T cells induced by infection with betacoronaviruses are long-lasting, supporting the notion that patients with COVID-19 will develop long-term T cell immunity."

Please keep in mind that testing "positive" for COVID doesn't mean you are infectious, and that's also true if you've already had COVID.

 

You can read more about that here.

 

 

 

 

Corroborating Information

 

An analysis of millions of coronavirus test results in Denmark found that people who had prior infection, were still protected 6 months after the initial infection.

 

Another study also found that individuals who recovered from the coronavirus developed "robust" levels of B cells and T cells (necessary for fighting off the virus) and,

"these cells may persist in the body for a very, very long time."

Dr. Daniela Weiskopf, Dr. Alessandro Sette, and Dr. Shane Crotty from the La Jolla Institute for Immunology analyzed immune cells and antibodies from almost 200 people who had been exposed to SARS-CoV-2 and recovered.

 

The researchers found durable immune responses in the majority of people studied.

 

Antibodies against the spike protein of SARS-CoV-2, which the virus uses to get inside cells, were found in 98% of participants one month after symptom onset.

 

As seen in previous studies, the number of antibodies ranged widely between individuals. But, promisingly, their levels remained fairly stable over time, declining only modestly at 6 to 8 months after infection.

 

Virus-specific B cells increased over time. People had more memory B cells six months after symptom onset than at one month afterwards.

 

Although the number of these cells appeared to reach a plateau after a few months, levels didn't decline over the period studied.

 

Levels of T cells for the virus also remained high after infection. Six months after symptom onset, 92% of participants had CD4+ T cells that recognized the virus.

 

These cells help coordinate the immune response. About half the participants had CD8+ T cells, which kill cells that are infected by the virus.

 

recent study published in Clinical Microbiology and Infection explains:

"Presence of cross-reactive SARSCoV2 specific Tcells in never exposed patients suggests cellular immunity induced by other coronaviruses.

 

Tcell responses against SARSC0V2 also detected in recovered Covid patients with no detectable antibodies…

 

"Cellular immunity is of paramount importance in containing SARSCoV2 infection… and could be maintained independently of antibody responses.

 

Previously infected people develop much stronger Tcell responses against spike protein peptides in comparison to infection-naive people after mRNA vaccine."

 

 

 

Final Thoughts & Important Considerations

 

It was great to see Dr. Ali Ellebedy bring up the point about reports earlier on and mainstream media claim that natural infection does not provide protection, and how this was a misinterpretation of the data.

 

This was done to stress the importance of vaccination. Anybody who was suggesting that natural infection was sufficient enough for long lasting protection at the time was, and still is subjected to extreme amounts of criticism and even censorship.

 

I recently published an article regarding Harvard epidemiologist and vaccine expert Dr. Martin Kulldorff.

 

He is one of many who has been subjected to censorship for claiming that previously infected people do not need to take the vaccine, and that everybody does not need to take the vaccine.

 

I also recently published an article about viral immunologist, Professor at the University of Guelph, and vaccine expert Dr. Bryan Bridle, who explained several concerns regarding the rollout of COVID vaccines and expressed how people are not being tested for antibodies before getting vaccinated.

 

This way the vaccines could perhaps go to those who actually need it.

 

The push for mass vaccination doesn't really add up and conform to the science. Telling people that nothing is going to go back to normal until everybody is vaccinated again, from a scientific standpoint, just doesn't make any sense. 

 

Dr. Sunetra Gupta, considered by many to be the world's preeminent infectious disease expert explained that the way COVID vaccines are being promoted and the idea that everybody needs to be vaccinated is unscientific and suspicious.

 

The general scientific consensus is that more than a billion people have been infected, which is why, for most people, the survival rate of COVID is extremely high, nearly 100 percent for healthy people under the age of 60.

 

If this is true, there are a number of people in the population who are already immune and do not require a vaccine.

 

Furthermore,

What happens to people who are vaccinated who've already had a COVID infection?

 

Does this change the immunity they've gained from natural infection?

I don't know but these are all very important questions.

 

Furthermore, questions of vaccine efficacy must be taken into consideration. You can read more about that here and here.

 

With all of this information and the sources available, does the idea of vaccine passports, or mandating vaccines to attend sporting events actually make sense at all?

 

If it doesn't, and if it's not black and white, then why is there such a strong push for these measures? Has science become politicized?

"I'm not aware of any vaccine out there which will ever give you more immunity than if you're naturally recovered from the illness itself…

 

If you've naturally recovered from it, my understanding as a doctor level scientist is that those antibodies will always be better than a vaccine, and if you know any differently, please let me know."

Dr. Suneel Dhand

 

 

 

 

 

 

 

Good news - Mild COVID-19 induces...

Lasting Antibody Protection
by Tamara Bhandari

May 24, 2021

from TheSource Website


 

 


People who have had a mild case of COVID-19

are left with long-term antibody protection against future disease,

according to a study from researchers at

 Washington University School of Medicine.

(Photo: Getty Images)
 

 

 

People who have had mild illness

develop antibody-producing cells

that can last lifetime...
 

 


Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine (WUSM) in St. Louis.

 

Such cells could persist for a lifetime, churning out antibodies all the while.

The findings, published May 24 in the journal Nature, suggest that mild cases of COVID-19 leave those infected with lasting antibody protection and that repeated bouts of illness are likely to be uncommon.

"Last fall, there were reports that antibodies wane quickly after infection with the virus that causes COVID-19, and mainstream media interpreted that to mean that immunity was not long-lived," said senior author Ali Ellebedy, PhD, associate professor of pathology and immunology, of medicine and of molecular microbiology.

 

"But that's a misinterpretation of the data. It's normal for antibody levels to go down after acute infection, but they don't go down to zero; they plateau.

 

Here, we found antibody-producing cells in people 11 months after first symptoms. These cells will live and produce antibodies for the rest of people's lives.

 

That's strong evidence for long-lasting immunity."

During a viral infection, antibody-producing immune cells rapidly multiply and circulate in the blood, driving antibody levels sky-high. Once the infection is resolved, most such cells die off, and blood antibody levels drop.

 

A small population of antibody-producing cells, called long-lived plasma cells, migrate to the bone marrow and settle in, where they continually secrete low levels of antibodies into the bloodstream to help guard against another encounter with the virus.

 

The key to figuring out whether COVID-19 leads to long-lasting antibody protection, Ellebedy realized, lies in the bone marrow.

 

To find out whether those who have recovered from mild cases of COVID-19 harbor long-lived plasma cells that produce antibodies specifically targeted to SARS-CoV-2, the virus that causes COVID-19, Ellebedy teamed up with co-author Iskra Pusic, MD, associate professor of medicine.

 

Ellebedy already was working with co-authors Rachel Presti, MD, PhD associate professor of medicine, and Jane O'Halloran, MD, PhD assistant professor of medicine, on a project to track antibody levels in blood samples from COVID-19 survivors.

 

The team already had enrolled 77 participants who were giving blood samples at three-month intervals starting about a month after initial infection. Most participants had had mild cases of COVID-19; only six had been hospitalized.

 

With Pusic's help, Ellebedy and colleagues obtained bone marrow from 18 of the participants seven or eight months after their initial infections. Five of them came back four months later and provided a second bone marrow sample.

 

For comparison, the scientists also obtained bone marrow from 11 people who had never had COVID-19.

 

As expected, antibody levels in the blood of the COVID-19 participants dropped quickly in the first few months after infection and then mostly leveled off, with some antibodies detectable even 11 months after infection.

 

Further, 15 of the 19 bone marrow samples from people who had had COVID-19 contained antibody-producing cells specifically targeting the virus that causes COVID-19. Such cells could still be found four months later in the five people who came back to provide a second bone-marrow sample.

 

None of the 11 people who had never had COVID-19 had such antibody-producing cells in their bone marrow.

"People with mild cases of COVID-19 clear the virus from their bodies two to three weeks after infection, so there would be no virus driving an active immune response seven or 11 months after infection," Ellebedy said.

 

"These cells are not dividing.

 

They are quiescent, just sitting in the bone marrow and secreting antibodies. They have been doing that ever since the infection resolved, and they will continue doing that indefinitely."

People who were infected and never had symptoms also may be left with long-lasting immunity, the researchers speculated.

 

But it's yet to be investigated whether those who endured more severe infection would be protected against a future bout of disease, they said.

"It could go either way," said first author Jackson Turner, PhD, an instructor in pathology and immunology.

 

"Inflammation plays a major role in severe COVID-19, and too much inflammation can lead to defective immune responses. But on the other hand, the reason why people get really sick is often because they have a lot of virus in their bodies, and having a lot of virus around can lead to a good immune response.

 

So it's not clear.

 

We need to replicate the study in people with moderate to severe infections to understand whether they are likely to be protected from reinfection."

Ellebedy and colleagues now are studying whether vaccination also induces long-lived antibody-producing cells.

 

 

 

 

Notes

Turner JS, Kim W, Kalaidina E, Goss CW, Rauseo AM, Schmitz AJ, Hansen L, Haile A, Klebert MK, Pusic I, O'Halloran JA, Presti RM, Ellebedy AH. - SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans - Nature. May 24, 2021. DOI: 10.1038/s41586-021-03647-4

 

This study was supported by,

  • the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH), grant numbers U01AI1419901, U01AI150747 and 5T32CA009547 and contract numbers HHSN272201400006C, HHSN272201400008C and 75N93019C00051

  • the Norwegian Research Council, grant number 271160

  • the University of Oslo's National Graduate School in Infection Biology and Antimicrobials, grant number 249062.

This study utilized samples obtained from the Washington University School of Medicine's COVID-19 biorepository supported by the NIH/National Center for Advancing Translational Sciences, grant number UL1 TR002345.

 

Washington University School of Medicine's 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals.

 

The School of Medicine is a leader in medical research, teaching and patient care, consistently ranking among the top medical schools in the nation by U.S. News & World Report.

 

Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.