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by Vance Voetberg
ibuprofen poses serious health risks that outweigh potential benefits...
But although this easily accessible over-the-counter drug could temporarily mask discomfort and sometimes eliminate pain, experts say it does little to spur true healing.
Even as it's considered one of the safer nonsteroidal anti-inflammatory drugs (NSAIDs) for the liver, ibuprofen can cause damage to liver cells, also known as hepatotoxicity or toxic hepatitis, according to a systematic review analyzing 22 studies.
This liver injury occurred within 12 days of starting treatment and was more common in women. As the body's detoxifier, the liver breaks down and assesses compounds.
Ibuprofen is challenging for the liver to process, Dr. Maroon said.
The standard dosage of 200 to 400 milligrams three times daily is burdensome for the liver.
Though ibuprofen overdose is rare, it can cause liver damage. A 2020 study from the University of California-Davis found that even moderate doses of ibuprofen may have more significant adverse effects on liver health than doctors realize.
Research in mice showed that,
Ibuprofen is also toxic to the kidneys, as it damages blood vessels that filter waste.
It's more common among those older than 45 and with kidney or liver problems, and those populations should avoid ibuprofen, according to Dr. Maroon.
2. People with Asthma
Asthma affects 1 in 12 Americans. It causes inflamed airways that produce excess mucus, leading to breathing issues.
Ibuprofen blocks inflammation pathways but can increase compounds called leukotrienes, causing bronchospasms, a tightening of the muscles that line the lung's airways.
A 2016 study published in Medicine linked short-term use of ibuprofen, aspirin, and diclofenac to asthma exacerbation.
Another 2019 study from Taiwan showed that ibuprofen has higher asthma attack risks than acetaminophen in young children if they had an ER visit or hospitalization the prior year.
3. People with Hypertension or Heart Failure
Studies show that ibuprofen and NSAIDs such as naproxen can raise blood pressure.
Two meta-analyses found that NSAID use causes a significant increase in mean blood pressure, especially in hypertensive patients, according to a review article published in Drug Safety.
One report noted that NSAID users had a 1.7 times higher risk of needing antihypertensives than nonusers. NSAID use was also linked to a 40 percent increased hypertension diagnosis risk.
Ibuprofen can also decrease the effects of blood pressure medications.
Given the link between high blood pressure and heart disease, Dr. Maroon said,
A 2016 study published in the British Medical Journal associated NSAID use with higher heart failure risk due to increased blood pressure, platelet inhibition, and other properties.
4. Pregnant Women
It's known that pregnant women should avoid NSAIDs after 20 weeks, as the drugs can result in low amniotic fluid, according to the U.S. Food and Drug Administration.
However, emerging research suggests that NSAIDs can also harm the baby in early pregnancy. One study found that ibuprofen reduced cell number, proliferation, and germ cell count regardless of gestational stage.
The adverse effects weren't fully reversed after stopping the drug for five days, indicating long-term effects...
A 2021 ex vivo study found that NSAIDs altered fetal kidney development as early as seven developmental weeks in several ways, including cell death.
Additional research has linked ibuprofen during pregnancy to,
5. People with Stroke History
Nerve pain after stroke is common.
However, taking NSAIDs for relief isn't recommended, according to Dr. Maroon. A systematic review of 15 studies found that NSAID use significantly raises the risk of hemorrhagic stroke.
Researchers attribute the increased stroke risk to vasoconstriction (the narrowing of blood vessels) and sodium excretion, worsening blood pressure.
A 2021 study found that women with menstrual pain using NSAIDs have a higher stroke risk.
NSAID use throughout periods is common.
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