
by Dr. Joseph Mercola
March 05, 2025
from
Mercola Website
PDF version

Story at-a-glance
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Osteoarthritis results from cartilage deterioration due
to genetic, metabolic and inflammatory factors, causing
bone friction, pain, stiffness and bone spur formation
that impair joint function
-
Studies show boosting vitamin K2 intake supports joint
health by regulating calcium metabolism, reducing
inflammation, boosting cartilage integrity and
activating proteins like GPX4 to protect cartilage cells
from damage
-
Elevated levels of vitamin K-dependent proteins like Gla-rich
protein (GRP) and matrix Gla protein (MGP) in
osteoarthritic joints suggest their protective role
against harmful calcium deposits and their use as
diagnostic markers
-
Insufficient vitamin K impairs protein activation,
allowing calcification, inflammation and cartilage
damage to progress unchecked, exacerbating
osteoarthritis symptoms and joint degeneration
-
Increasing vitamin K2 intake through foods, supplements
and healthy lifestyle changes offers a powerful approach
to preserving joint health, reducing inflammation and
slowing osteoarthritis progression
Osteoarthritis is a condition that primarily affects older adults.
It develops when cartilage, the cushion between bones, deteriorates
due to genetic, metabolic or inflammatory factors.
This causes bones
to rub together, leading to pain, stiffness and changes in the
underlying bone structure, such as osteophytes (bone spurs), which
further limit joint function.
Genetic predisposition plays a significant role in the development
of osteoarthritis, as certain individuals are more susceptible to it
due to inherited traits.
Metabolic factors such as obesity
contribute to increased stress on joints, accelerating cartilage
wear and tear. Inflammatory processes within the joint also
exacerbate cartilage degradation.
Conventional treatments, like pain relievers and physical therapy,
often focus on managing the symptoms rather than addressing the root
causes.
While they provide temporary relief, they do not stop the
progression of joint damage.
Some medications also have side
effects, including gastrointestinal issues and increased
cardiovascular risks.
Instead of relying solely on these treatments, consider alternative
approaches that target the root causes of osteoarthritis.
Nutrients
like vitamin K - both K1 (phylloquinone) and K2 (menaquinones) - have shown promise in supporting joint health, promoting cartilage
integrity and slowing disease progression - offering a safer and
more effective way to protect your joints and improve mobility.
What's the Role
of Gla-Rich Protein and Matrix Gla Protein in Osteoarthritis?
A study published in the Journal of Clinical Medicine 1
investigated the role of two vitamin K-dependent proteins - Gla-rich
protein (GRP) and matrix Gla protein (MGP) - in the development of
osteoarthritis.
Researchers compared the levels of these proteins in
the joint fluid of patients with and without osteoarthritis.
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GRP levels are significantly higher in
osteoarthritis
The researchers selected 26 patients diagnosed with
osteoarthritis who were undergoing knee replacement surgery and 31
individuals without osteoarthritis undergoing knee-related
procedures for non-cartilage-related issues.
Their analysis revealed that GRP levels were significantly higher in
the osteoarthritic group, with a mean of 419.61 ng/mL, compared to
382.18 ng/mL in the non-osteoarthritic group.
-
MGP levels are also elevated in osteoarthritic joints
The study
also found that MGP levels were elevated in osteoarthritic patients,
with averages of 67.76 ng/mL versus 53.49 ng/mL in the controls.
Calcium ion levels were also notably higher in those with
osteoarthritis, indicating a link between calcium metabolism and
joint degeneration.
-
Age influences MGP but not GRP
Interestingly, the study
identified a positive correlation between MGP levels and age,
reducing its specificity as an osteoarthritis biomarker.
In
contrast, GRP levels showed no significant age-related variation,
making GRP a more reliable indicator of this condition.
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GRP and MGP protect against calcium buildup
The elevated GRP and
MGP are believed to play a protective role against unwanted calcium
deposits in the joints, which lead to further cartilage damage.
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Vitamin K is essential for GRP and MGP function
Vitamins K1 and
K2 are essential for these proteins to function properly (although
vitamin K2 is more important for these proteins in tissues outside
the liver), as it helps them bind calcium effectively.
Without
adequate vitamin K, the ability of GRP and MGP to prevent calcium
buildup is compromised, exacerbating osteoarthritis symptoms.
Overall, the findings highlight the importance of GRP and MGP as
useful markers for early diagnosis and underscore the importance of
vitamin K in joint health 2
How Does
Vitamin K Protect Against Osteoarthritis?
A comprehensive review published in Nutrients 3 examined
the existing body of research on vitamin K1 and K2 and their effects
on osteoarthritis (OA), particularly their ability to prevent or
mitigate the severity of this condition by influencing cartilage
calcification and joint inflammation. Key findings for each include:
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Vitamin K1 is lower in OA patients
Individuals with OA had lower
serum K1 levels than healthy controls.
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Low plasma K1 is linked to mobility limitations
Plasma K1 levels
below 0.5 nmol/L were associated with more severe mobility
limitations, while a threshold of 1 nmol/L was identified for OA
prevention.
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K1 supplementation slows joint deterioration
A clinical trial
using 500 micrograms of K1 per day for three years showed a 47%
reduction in joint space narrowing in K1-deficient patients.
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Higher dietary K1 intake reduces OA severity
Studies found a
correlation between higher K1 intake and decreased OA severity.
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Vitamin K2 is unevenly distributed in OA joints
In OA patients,
higher K2 levels were found in the outer part of the knee joint
compared to the inner part. However, only one included study
specifically examined K2 distribution in knee joints.
To better understand the unique functions of vitamin K1 and K2, read
"Vitamin K1 vs. K2
- Understanding Their Distinct Roles in Your
Health."
How does Low K1 Levels exacerbate
Osteoarthritis Severity?
The comprehensive review published in Nutrients also found that
individuals with adequate vitamin K1 levels had a lower risk of
osteoarthritis and less severe joint damage compared to those with
vitamin K deficiency. 4
"Increased plasma phylloquinone level was linked to increased medial cartilage
thickness," the authors reported.
"Subjects with vitamin K
deficiency was found to have higher scores of Western Ontario
McMaster Scale (WOMAC), which reflects an increased severity of the
disease."
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Vitamin K1 regulates calcification in joint cartilage
Vitamin K1
acts as a cofactor for γ-glutamyl carboxylase, an enzyme that
activates γ-carboxyglutamate (Gla)-containing proteins, which
regulates calcification.
By activating these proteins, vitamin K1
mitigates the inappropriate buildup of calcium in joint cartilage,
which contributes to cartilage degradation and joint pain, both
hallmarks of osteoarthritis.
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Vitamin K1 supports MGP function to prevent cartilage
calcification
By activating MGP, which is essential in inhibiting
bone morphogenetic protein-mediated cartilage calcification.
By
activating these proteins, vitamin K1 maintains the structural
integrity of the cartilage, inhibiting the calcification process
that leads to osteoarthritis.
"Gla-rich proteins also inhibit inflammatory cascade in monocytic
cell lines, but this function might be independent of vitamin K-carboxylation,"
the authors added. 6
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Higher vitamin K1 intake correlates with healthier joints
The
researchers also found a notable correlation between higher vitamin
K1 intake and healthier joints, with individuals showing fewer signs
of joint degeneration, such as reduced bone spur formation and
preserved joint space width.
These structural improvements are
important markers of how vitamin K influences joint health.
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Vitamin K1 deficiency leads to increased joint damage
Additionally, the findings revealed that insufficient vitamin K1
levels, as indicated by higher plasma levels of inactive MGP, were
linked to more severe osteoarthritis symptoms like meniscus damage,
osteophytes and bone marrow lesions.
This indicates that inadequate
vitamin K1 prevents the proper activation of MGP, allowing
calcification and inflammation to progress unchecked.
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Even subclinical vitamin K deficiency contributes to
osteoarthritis
The research concluded that even subclinical
vitamin K deficiency was associated with the development of
radiographic knee osteoarthritis and cartilage lesions, underscoring
the nutrient's essential role in avoiding cartilage damage.
Maintaining adequate vitamin K levels, therefore, preserves
cartilage integrity and helps delay or prevent the onset of
osteoarthritis. 7
To learn more about how vitamin K supports bone health, check out
"Vitamin K 101
- Essential Basics for Bone and Heart Health."
How Does Vitamin K2 Mitigate Osteoarthritis Progression?
While the study above focused on vitamin K1, a June 2024 study
published in Biomedicine and Pharmacotherapy 8
investigated vitamin K2's role in slowing down the progression of
osteoarthritis.
The researchers focused on two main areas:
...which is essential for healthy joints.
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Vitamin K2 strengthens bones and cartilage and reduces joint pain
The study used both animal models and laboratory experiments. In
animal-induced osteoarthritis, vitamin K2 was administered to
observe its effects on joint health.
In parallel, cartilage cells were treated with vitamin K2 in a
controlled lab environment to determine its direct impact on these
cells.
The findings revealed that vitamin K2 not only increased bone
mass and cartilage thickness but also significantly reduced joint
pain and structural damage. 9
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Vitamin K2 prevents cartilage cell death
The results showed that
vitamin K2 increases the production of GPX4, a protein that protects
cells from ferroptosis, a type of programmed cell death that
contributes to cartilage degradation in osteoarthritis.
By boosting
GPX4 levels, vitamin K2 keeps cartilage cells alive and functioning
properly.
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Vitamin K2 blocks inflammation-driven cartilage damage
Vitamins
K2 protects the cartilage from excessive breakdown by interfering
with the MAPK/NFκB signaling pathway, which is responsible for
promoting inflammation and further cartilage damage in
osteoarthritis. 10
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Vitamin K2's effects are dose-dependent
The research showed that
vitamin K2's effects are dose-dependent.
Higher doses of vitamin K2
led to greater increases in GPX4 expression and more significant
reductions in markers of cartilage degradation. 11
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Vitamin K2 reduces oxidative stress and cellular damage
The
research showed that vitamin K2 treatment improved cartilage cell
viability, keeping more cells healthy and active, as well as reduced
the levels of reactive oxygen species (ROS), which are harmful
molecules that cause oxidative stress and damage to cells.
Moreover, vitamin K2 lowered the levels of intracellular
malondialdehyde (MDA), a marker of lipid peroxidation, a process
that damages cell membranes. 12
These findings highlight the importance of maintaining adequate
vitamin K2 intake to support joint integrity, reduce inflammation
and slow osteoarthritis progression.
Egg Yolks Are Your Best Dietary
Source of Vitamin K2 as MK-4
Egg yolks are among the highest dietary sources of Menaquinone-4
(MK-4), a vital form of vitamin K2 that plays an important role in
bone health, cardiovascular function and calcium regulation.
Including egg yolks in your diet significantly contributes to your
MK-4 intake, supporting various aspects of your health.
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Choose eggs from properly fed chickens
Most commercial egg
sources - even free-range organic - have high PUFA levels as they
are fed grains like soy and corn.
Ideally chickens should be fed
rice, barley and split peas.
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Eggs from low-PUFA-fed chickens are superior
I personally eat
six egg yolks a day from chickens who are fed this and have 80% less linoleic acid than regular chickens.
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How egg yolks compare as a leading MK-4 source
Below is a
comprehensive overview of egg yolks as a top source of MK-4, along
with additional dietary sources and considerations.

To ensure you're choosing the highest-quality eggs for optimal
nutrition, read "How to Decode Egg Carton Codes."
Five Tips to Optimize your Vitamin
K Levels for Healthier, Pain-Free Joints
By increasing your vitamin K1 and K2 levels through a nutritious
diet, proper supplementation and lifestyle modifications, you'll be
able to maintain healthy cartilage and joint function while
alleviating pain and stiffness.
In addition to eating more egg
yolks, here are five additional ways to optimize your vitamin K
intake and tackle osteoarthritis at its core:
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Eat more leafy greens
Vitamin K1 (phylloquinone) is found in
all photosynthetic plants, with green leafy vegetables being the
primary dietary source.
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Add vitamin K2-rich foods into your diet
Prioritize foods
naturally rich in vitamin K2, especially the MK-7 form, which is
more bioavailable and remains active in the body longer.
Fermented
foods like
natto are the most potent source, delivering
approximately 11 micrograms (mcg) of K2 MK-7 per gram of serving.
Other good options include sauerkraut made with K2-producing
bacteria and certain cheeses like Gouda, brie and Edam.
Homemade
fermented vegetables prepared with starter cultures designed to
enhance K2 production provide up to 500 mcg of K2 per 2-ounce
serving.
Additionally, grass fed beef, butter and eggs are far
superior to grain-fed options, offering significantly higher levels
of this essential nutrient.
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Consider supplementing with vitamin K2 MK-7
Take 180 to 200 mcg
of vitamin K2 MK-7 daily to activate proteins that prevent
inappropriate calcium deposits in your joints.
This form is more
effective for targeting joint tissues and preserving cartilage
integrity because it has better absorption and a longer half-life.
For optimal absorption, consume it with a meal containing healthy
fats.
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Combine vitamin K2 with vitamin D3 and magnesium threonate
Enhance calcium metabolism by pairing vitamin K2 with vitamin D3 and
magnesium threonate daily.
This combination works synergistically - vitamin K2 directs calcium to bones instead of soft tissues, while
vitamin D3 aids in its absorption.
To determine your ideal dosage for magnesium, take magnesium citrate
first, gradually increasing your dose until you experience loose
stools, then reduce it slightly - that's your ideal dose.
Afterward,
transition to magnesium threonate, which doesn't cause loose stools
like magnesium citrate.
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Replace vegetable oils with healthy fats
Remove vegetable oils
from your diet, as they worsen inflammation and contribute to joint
damage. Instead, choose nutrient-dense, anti-inflammatory
alternatives such as tallow, ghee or grass fed butter.
Focus on consuming whole, unprocessed foods to further reduce
inflammatory triggers and support your body's natural repair
processes.
This change not only protects your joints but also
enhances the effectiveness of vitamin K2 in maintaining cartilage
integrity and promoting overall joint health.
Frequently Asked Questions (FAQs)
about Osteoarthritis and Vitamin K
Q: What causes osteoarthritis?
A: Osteoarthritis develops when cartilage deteriorates due to
genetic, metabolic or inflammatory factors. This leads to bones
rubbing together, causing pain, stiffness and structural changes
like bone spurs that impair joint function.
Q: How does vitamin K help with osteoarthritis?
A: Vitamin K plays an essential role in preventing cartilage
calcification and inflammation. Both vitamin K1 and K2 activate
proteins that regulate calcium, protecting joints from excessive
wear and degradation.
Q: Can a vitamin K deficiency worsen osteoarthritis?
A: Yes. Low vitamin K levels are linked to increased cartilage
degradation, joint pain and reduced mobility. Deficiency prevents
essential proteins like matrix Gla protein (MGP) from stopping
calcium buildup in joints, accelerating osteoarthritis progression.
Q: Should I take a vitamin K2 supplement for joint health?
A: If your diet lacks sufficient vitamin K2, supplementation with
MK-7 (180 to 200 mcg daily) helps activate proteins that prevent
calcium deposits in joints and support cartilage integrity.
Q: What are the best ways to optimize vitamin K levels for
osteoarthritis prevention?
A: Increase your intake of vitamin K-rich foods, supplement with K2
if needed, pair it with vitamin D3 and magnesium, and eliminate
inflammatory vegetable oils from your diet to support joint health.
References
1, 2
J
Clin Med. 2024 Aug 30;13(17):5159
3, 4, 6, 7
Nutrients. 2020 Apr 25;12(5):1208
5
The Egyptian Rheumatologist July 2016; 38(3): 217-223
8, 9, 10, 11, 12
Biomedicine & Pharmacotherapy, Volume 175, June 2024, 116697
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