by Sayer Ji
November 28, 2014
A groundbreaking study
published this month in Nature
challenges a century-old
about the innate pathogenicity
of these extremely small,
known as viruses.
enteric virus can replace the beneficial function of commensal
bacteria," researchers found that an,
"enteric RNA virus can replace the
beneficial function of commensal bacteria in the intestine."
Known as murine (mouse) norovirus (MNV),
researchers found that infecting germ-free or antibiotic-treated
mice infection with MNV,
"restored intestinal morphology and
lymphocyte function without inducing overt inflammation and
The researchers found:
Importantly, MNV infection offset
the deleterious effect of treatment with antibiotics in models
of intestinal injury and pathogenic bacterial infection.
These data indicate that eukaryotic
viruses have the capacity to support intestinal homeostasis and
shape mucosal immunity, similarly to commensal bacteria.
Despite the commonly held belief that
viruses are vectors of morbidity and mortality that must be
vaccinated against in order to 'save us' from inevitable harm and
death, the new study dovetails with a growing body of research
showing that our own genome is
80% viral in origin.
Reporting on the new study, in an
article well worth reading the
Science Daily states:
The new findings are the first
strong evidence that viruses in the gastrointestinal tract can
help maintain health and heal a damaged gut.
They summarized the study's findings as
The team infected germ-free mice and
antibiotic-treated mice with MNV and found that the infection
triggered the repair of intestinal tissue damaged by
inflammation, restored intestinal cell numbers, restored
intestinal cell function, and normalized tissue architecture.
The results were apparent after just
2 weeks of MNV infection.
Infection with MNV also helped
restore the gut's immune system. The investigators do not yet
know how the virus supports the immune system. They did find,
however, increased signaling by antiviral type 1 interferon
proteins, suggesting the virus was playing a key role in driving
the immune response.
The investigators also documented a
doubling of T-cell levels in the blood and detectable levels of
antibodies in the gut and blood of antibiotic-treated mice after
MNV infection. These measures were consistent with a
normalization of the immune response. The authors conclude that
viral infection of the gut may be helpful once antibiotic
treatment has wiped out intestinal bacteria.
Treatment with MNV was also able to
improve survival in antibiotic-treated mice receiving the
damaging chemical dextran sodium sulphate.
As our knowledge of the critical role of
microbes increases, a paradigm-shift is occurring in medicine that
is only beginning to trickle down to clinical practice.
If our very identity depends on 'germs'
- e.g. the bacteria within our body account for 10 times more cells
and 99% more genetic material that found in the human body itself -
the discovery that the viruses in our body - the total number
referred to as
the virome - also perform indispensable functions in
supporting and maintaining our health, turns on its head widely held
assumptions about their role in contributing to human disease and
As reported in the Science Daily article, the senior investigator of
the study Ken Cadwell, PhD, from New York University, states:
We have known for a long time that
people get infected all the time with viruses and bacteria, and
they don't get sick.
Now we have scientific evidence that not
every viral infection is bad, but may actually be beneficial to
health, just as we know that many bacterial infections are good
for maintaining health.
Consistent with the 'hygiene
hypothesis,' natural infections during childhood and onward, may
prime our immune system and help to balance the Th1 (innate) and Th2
(adaptive) poles of immunity, producing a healthy immune system as a
Vaccines, by disrupting this
evolutionarily determined balance, may be contributing to widespread
immune dysregulation, both suppressing innate immune mechanisms as
well as over-stimulating the adaptive pole, contributing to
widespread autoimmunity in exposed populations.
As science and molecular biology progresses and continues to reveal
the inherent intelligence within the
commensal relationship of the
human body to the microbial universe, we are left with a crucial
Is the present-day globally
orchestrated vaccine agenda really improving health, or does it
belie a hubris that shirks the scientific evidence in favor of
an agenda that wishes to exert control over the human body due
to economic and socio-political agendas?
For additional research on why
vaccines do not make sense evolutionarily, read our article on the