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by Dr. Joseph Mercola
January 02, 2024
from
Mercola Website
Story
at-a-glance
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According to
research published in December 2023, the mRNA COVID
shots suffer high rates of ribosomal "frameshifting,"
which causes your cells to produce off-target proteins
that can trigger unintended immune reactions
-
According to
the authors, off-target cellular immune responses occur
in 25% to 30% of people who have received the COVID shot
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The U.S. Food
and Drug Administration and Australia's Therapeutic
Goods Administration are refusing to release the RNA
stability data they supposedly relied on when approving
a change to Pfizer's shot that allowed it to be
transported and stored at temperatures of -20 degrees
Celsius instead of -70 C
-
The FDA also
authorized Pfizer to swap the phosphate-buffered saline
buffer used in the adult formulations, to a tromethamine
(Tris) buffer in the children's version. FDA did not
require any kind of testing to be conducted, and no data
have been released in support of its decision to allow
the swap
-
According to
research published in 2023, the nanolipid in Comirnaty,
made by Pfizer/BioNTech, is toxic to cells and triggers
proinflammatory cytokines and reactive oxygen species
that can disrupt the mitochondrial membrane causing it
to release its content, cause RNA mistranslation, DNA
mutations, destruction of the nuclear membrane and more.
Frequent repetitions of COVID boosters and/or using mRNA
in other vaccines poses a grave public health risk, the
scientist warns
Red Alert:
This 'Hidden Database' Could Prevent Future Pandemics
It's normal to start inquiries into mass deaths
by asking how they
happened
- so you can stop them from happening again.
So why is the
'scientific' community
(despite this heck of a coincidence)
playing it
fast and loose with COVID,
by refusing to release this database...?
According to research published in the December 6, 2023, issue of
Nature, the mRNA COVID shots suffer from high rates of ribosomal "frameshifting,"
which causes your cells to produce off-target proteins with unknown
effects. 1,2,3
As explained in that paper:
4
"A key feature of therapeutic IVT [in vitro-transcribed] mRNAs is
that they contain modified ribonucleotides, which have been shown to
decrease innate immunogenicity and can additionally increase mRNA
stability, both of which are favorable characteristics for mRNA
therapies ...
Pseudouridine (Ψ) is known to increase misreading of mRNA stop
codons in eukaryotes, and can affect misreading during prokaryotic
mRNA translation. 1-methylΨ does not seem to affect codon
misreading, but has been shown to affect protein synthesis rates and
ribosome density on mRNAs, suggesting a direct effect on mRNA
translation ...
Here we demonstrate that incorporation of N1-methylpseudouridine
into mRNA results in +1 ribosomal frameshifting in vitro and that
cellular immunity in mice and humans to +1 frameshifted products
from BNT162b2 vaccine mRNA translation occurs after vaccination.
The +1 ribosome frameshifting observed is probably a consequence of
N1-methylpseudouridine-induced ribosome stalling during IVT mRNA
translation, with frameshifting occurring at ribosome slippery
sequences ...
[T]hese data highlight potential off-target
effects for future mRNA-based therapeutics and demonstrate the
requirement for sequence optimization."
Synthetic RNA
Is Frequently Misread
In layman English,
the inclusion of synthetic methylpseudouridine
causes the ribosomes (which are responsible for reading the code) to
misread the RNA's instructions.
RNA code consists of groups of three
bases (codons) that must be read in the correct order for a desired
protein to be created.
Because the methylpseudouridine is not a perfect fit, it causes the
decoding process to stall and shift (hence the term "+1 ribosomal
frameshifting").
There's basically a stutter in the decoding
process, as your cells don't understand what's being asked for, and
this stuttering causes the decoding to skip a letter, thereby
garbling the entire code.
As a result, unintended "nonsensical" proteins are produced instead
of the desired SARS-CoV-2 spike.
That, in turn, means that your
immune system will not produce antibodies against SARS-CoV-2, but
rather against these aberrant proteins.
According to the authors, off-target cellular immune responses occur
in 25% to 30% of people who have received the COVID shot, and as
noted by molecular virologist David Speicher Ph.D.: 5
"Whenever our cells
create an abundance of unintended proteins or prevent production
of appropriate proteins it could lead to an unintended immune
response with a huge potential to cause harm."
Not knowing exactly what proteins are being produced is far from the
only problem with these gene-based shots, though.
Why Are
Regulators Hiding RNA Stability Data?
As reported by investigative journalist Maryanne Demasi, Ph.D., the
U.S. Food and Drug Administration (FDA) and Australia's Therapeutic Goods
Administration both refuse,
to release the RNA stability data they
supposedly relied on when approving a change to
Pfizer's shot that
allowed it to be transported and stored at temperatures of -20
degrees Celsius instead of -70 C.
Pfizer has also refused to disclose those data.
Why is that?
What do
the data reveal that they don't want us to see?
Demasi writes: 6
"... when the FDA granted authorization
7 in December 2020, it
specified the vaccine had to be stored between -80ºC and -60ºC,
requiring special ultra-cold freezers, which proved challenging to
areas with limited resources.
But by February 2021, Pfizer had apparently solved the problem.
It
submitted new 'RNA stability data' to the FDA demonstrating the
vaccine could be stored in conventional freezers (-20ºC) and no
longer required ultra-cold freezers.
The FDA approved 8 the change swiftly.
Two months later, Australia's
Therapeutic Goods Administration (TGA) also approved
9 Pfizer's
application, allowing unopened vials to be stored at -20ºC for up to
2 weeks.
Storage temperature wasn't the only change.
Drug regulators also
approved extensions to the vaccines' expiry dates. Various batches
of Pfizer's vaccine, for example, had their expiry dates extended by
one year (FDA) 10 or 6 months (TGA). 11
But given the
sensitivity of RNA to changes in temperature and storage
duration, what stability data did the regulators rely on to
green-light these decisions?"
As it stands, we have no idea, and that's a problem.
As Phillip
Altman, who has more than four decades of experience in clinical
trials and regulatory affairs, told Demasi, 12
"It's critically
important to know about the stability of RNA in the vaccines
because if the RNA disintegrates, then the efficacy of the
vaccine goes down."
Of course, over the past three years, evidence conclusively shows
that the shots are near-useless when it comes to efficacy.
What's
worse,
efficacy actually becomes negative after a few months,
meaning they leave you more prone to infection than your unjabbed
peers...
Does RNA Instability
Have Something to Do With 'Hot Lots'?
Altman is also concerned about safety, because data reveal some
shots contain far higher doses of mRNA than others, and such "hot
lots" are associated with more
adverse events and deaths. 13
Mounting
research shows the shots do not contain "nothing but intact RNA."
They also contain fragments of RNA, as well as bits of DNA, both of
which can have deleterious health effects.
Demasi quotes David
Wiseman, Ph.D., a research bioscientist involved in medical product
development, who told her: 14
"We need to know
about the bits of RNA that are not intact. It's possible that
small fragments of mRNA also have biological effects such as
inflammation or controlling how other RNA works."
What Data Did
FDA Rely on When Authorizing Buffer Swap?
The FDA also authorized another swap that affected RNA stability,
and in this case, they appear to have done so without any testing
whatsoever.
In October 2021, Pfizer amended the formulation of its COVID jab
for children aged 5 to 11 years, swapping out the
phosphate-buffered saline used in the adult formulations, to a tromethamine (Tris)
buffer. 15
The reason for the swap was to improve the stability profile of the
shot, allowing the mRNA to resist degradation so it could be stored
for up to 10 weeks in a standard freezer.
The FDA authorized the
swap in mid-December that year, 16 but as Wiseman told Demasi:
17
"If the new buffer helped stabilize the mRNA, then it would probably
impact the amount of spike protein being produced or alter the way
the lipid nanoparticles behaved in the body.
But where were the
data when the FDA made that decision? The FDA never insisted the
new formulation be tested, at least in animals, before it was
injected into children."
Considering the shots were intended for healthy children, why did
they not insist on additional testing?
"It's time for regulators to restore public trust and release these
sorts of data.
Until then, why should we inject anyone, especially
children, with a vaccine without disclosing these, and other kinds
of data?" Wiseman says. 18
Scientist
Warns of Intrinsic Cytotoxicity of Nanolipid
Video Link
The safety of the nanolipid used to encase the mRNA in the shots is
also being questioned.
In the video above, independent researcher
Gabriele Segalla, an Italian biochemist who specializes in the
chemistry of microemulsions and colloidal systems, discusses his
findings, presented in two peer-reviewed reports published in the
International Journal of Vaccine Theory, Practice and Research (IJVTPR).
The first, published in late January 2023, titled "Chemical-Physical
Criticality and Toxicological Potential of Lipid Nanomaterials
Contained in a COVID-19 mRNA Vaccine," 19 details the toxic potential
of the nanolipid in Comirnaty, made by Pfizer/BioNTech.
Importantly,
this paper highlights the potential for reactive oxygen species (ROS)
formation in various organs, including the kidneys, liver, heart and
brain.
According to this paper:
"Of particular concern is the presence in the formulation of the two
functional excipients, ALC-0315 and ALC-0159, never used before in a
medicinal product, nor registered in the European Pharmacopoeia, nor
in the European C&L inventory.
The current Safety Data Sheets of the manufacturer are omissive and
non-compliant, especially with regard to the provisions of current
European regulations on the registration, evaluation, authorization
and restriction of nanomaterials.
The presence of electrolytes in the preparation and the subsequent
dilution phase after thawing and before inoculation raise
well-founded concerns about the precarious stability of the
resulting suspension and the Polydispersity index of the
nanomaterials contained in it, factors that can be hypothesized as
the root causes of numerous post-vaccination adverse effects
recorded at statistical-epidemiological level."
mRNA
'Vaccines' Pose Grave Public Health Risks
The second paper, "Apparent Cytotoxicity and Intrinsic Cytotoxicity
of Lipid Nanomaterials Contained in a COVID-19 mRNA Vaccine,"
20
published in mid-October 2023, focuses on the nanolipid ALC-0315.
The nanolipid in Comirnaty is toxic to cells and triggers
pro-inflammatory cytokines and reactive oxygen species that can
disrupt the mitochondrial membrane causing it to release its
content, cause RNA mistranslation, DNA mutations, destruction of the
nuclear membrane and more.
It describes how ALC-0315 - one of the molecules used to create Comirnaty's nanoparticle delivery system
- forms,
"proinflammatory
cytokines and ROS that can disrupt the mitochondrial membrane
and release its content, cause RNA mistranslation,
polymerization of proteins and DNA, DNA mutations, destruction
of the nuclear membrane and consequent release of its content."
"Thus, the prospect of frequently repeated COVID 'booster shots,'
and also that of extending mRNA technology to vaccines against other
pathogens or non-infectious diseases, conjures up a very grave
public health risk," he writes.
According to Segalla, the ALC-0315,
"is not suitable for
intramuscular application" for a number of reasons, including the
fact that it does not allow for the "proper transfection of host
cells, despite what is stated by EMA (European Medicines Agency)
in its Assessment report dated 19 February 2021, in flagrant
contradiction with the same bibliographic source therein cited."
In short,
the nanolipid particles are
toxic to cells, and can
"shed
in unpredictable biological locations, even far from the site of
inoculation," due to their "exceptional penetrability, mobility,
chemical reactivity and systemic accumulation."
The nanolipid used
in the shots,
"can lead to an unprecedented medical disaster,"
Segalla warns.
He's now calling for the
immediate suspension of
their use...
Resources for
Those Injured by the COVID Jab
Based on data from across the world, it's beyond clear that
the COVID shots are the most dangerous drugs ever deployed...
If you
already got one or more COVID jabs and are now reconsidering, you'd
be wise to avoid all vaccines from here on, as you need to end the
assault on your body.
Even if you haven't experienced any obvious
side effects, your health may still be impacted long-term, so don't
take any more shots.
If you're suffering from side effects, your first order of business
is to eliminate
the spike protein - and/or any aberrant off-target
protein - that your body is producing.
Two remedies shown to bind to
and facilitate the removal of SARS-CoV-2 spike protein are,
I don't know if these drugs will
work on off-target proteins and nanolipid accumulation as well, but
it probably wouldn't hurt to try.
The Front Line COVID-19 Critical Care Alliance (FLCCC) has developed
a post-vaccine treatment protocol called
I-RECOVER.
Since the
protocol is continuously updated as more data become available, your
best bet is to download the latest version straight from the FLCCC
website at covid19criticalcare.com. 21
For additional suggestions, check out the
World Health Council's
spike protein detox guide, 22 which focuses on natural substances
like herbs, supplements and teas.
Sauna therapy can also help
eliminate toxic and misfolded proteins by stimulating
autophagy...
Sources and References
1, 4 Nature
December 6, 2023
2, 5 Trial
Site News December 7, 2023
3 The
Telegraph December 6, 2023
6, 12, 14, 17, 18 Blog.maryannedemasi.com
December 18, 2023
7 Reuters
February 25, 2021
8 FDA
February 25, 2021
9 TGA.gov.au
April 8, 2021
10 FDA
December 22, 2022
11 Australian
Government Dept of Health and Aged Care
13 European
Journal of Clinical Investigation March 30, 2023; 53(8): e13998
15 Blog.maryannedemasi.com
July 26, 2022
16 FDA
December 17, 2021
19 International
Journal of Vaccine Theory, Practice and Research January 2023;
3(1): 787-817
20 International
Journal of Vaccine Theory, Practice and Research October 2023;
3(1): 957-972
21 Covid19criticalcare.com
22 World
Council for Health Spike Protein Detox Guide November 30, 2021
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